Recovery from spindle checkpoint-mediated arrest requires a novel dnt1-dependent apc/c activation mechanism

HIGHLIGHTS

SUMMARY

By contrast, the spindle checkpoint-silencing mechanisms in fungi remains Nucleolar protein Dnt1 is involved in inhibiting MCC-APC/C association and maintaining Cdc20 stability less well explored, limiting the full understanding about this key cellular process. The authors identified Dnt1 as a novel factor involved in inhibiting excessive and prolonged MCC-APC/C association and promoting Slp1Cdc20 stability, and thus it ensures timely spindle checkpoint inactivation, which is essentially required for maintaining cell viability upon recovery from the inhibition of APC/C by checkpoint. September 15, 2022 Nucleolar protein Dnt1 is involved in . . .

 



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