Recurrent translocations in topoisomerase inhibitor-related leukemia are determined by the features of dna breaks rather than by the proximity of the translocating genes

HIGHLIGHTS

  • who: Nikolai A. Lomov et al. from the Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia have published the paper: Recurrent Translocations in Topoisomerase Inhibitor-Related Leukemia Are Determined by the Features of DNA Breaks Rather Than by the Proximity of the Translocating Genes, in the Journal: (JOURNAL) of 25/06/2022

SUMMARY

    Published maps and institutional affil- Targeting topoisomerase II is an effective treatment approach in cancer chemotherapy. DNA topoisomerase II (TopoII) plays a critical role in replication and transcription, where it resolves DNA catenanes and relieves . . .

     

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