Recycling of memory b cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

HIGHLIGHTS

  • who: Yang Zhang from the Institute University of, Charitéplatz, Berlin, Germany have published the research work: Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift, in the Journal: Rheumatology and Clinical Immunology, Charité -
  • what: The authors show that the migration to the SCS and back is organized S1P and CCL21, respectively, and present data supporting the hypothesis that memory B cell recycling may be a mechanism to survey for and adapt to antigen variants. The experiments suggest that S1PR directs the migration of memory . . .

     

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