HIGHLIGHTS
- who: Mounir Benkoulouche from the Toulouse Biotechnology Institute have published the research: Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens, in the Journal: Scientific Reports Scientific Reports
- what: The study shows how amino_acid substitutions introduced in the acceptor subsites + 1, + 2 and + 3 of ΔN123-GBD-CD2 branching sucrase could drastically shift the preferred binding mode of a non-natural tetrasaccharide acceptor, a lightly protected precursor in the synthesis of S. flexneri haptens, and thereby control its regioselective . . .
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