Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity

HIGHLIGHTS

  • who: Ayman Grada from the Raffaele University, Italy have published the article: Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity, in the Journal: (JOURNAL)
  • what: Blood-brain barrier penetration study Brief results of this study have been reported previously .
  • how: In the first analysis the authors examined the ability of sarecycline to penetrate the bloodbrain barrier relative to minocycline in a rat model study.

SUMMARY

    The authors investigated the potential relationship between the brain-penetrative and lipophilic attributes of sarecycline . . .

     

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