Reduced c9orf72 expression exacerbates polygr toxicity in patient ipsc-derived motor neurons and a type i protein arginine methyltransferase inhibitor reduces that toxicity

HIGHLIGHTS

• who: Therese L. Dane from the University of Eastern Finland, Finland have published the paper: Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity, in the Journal: (JOURNAL)
• what: Discussion: This study explores the interplay of loss-of-function and gain-offunction toxicity in C9orf72 ALS. The authors show that human iPSC-derived MNs lacking one or both of the C9orf72 alleles are more susceptible to polyGR15 repeat toxicity.
• how: Indicated that the Type I PRMT inhibitor MS023 significantly . . .
  

   

  

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