Reduced expression of the psychiatric risk gene dlg2 (psd93) impairs hippocampal synaptic integration and plasticity

HIGHLIGHTS

• who: Simonas Griesius from the Animals and husbandry All procedures were carried out under local institutional guidelines, approved by the University of Bristol Animal Welfare and Ethical Review Board, and in accordance with the UK Animals (Scientific procedures) Act The experiments employed a novel Dlg2+/- heterozygous rat model generated on a Hooded Long Evans background using CRISPRCas, genomic engineering that targeted a , bp deletion to exon , of the rat Dlg, gene, resulting in a downstream frame shift in exon , and the production of a premature stop codon that led to a reduction in Dlg, protein levels in . . .
  

   

  

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