Reduced ran expression and disrupted transport between cytoplasm and nucleus; a key event in alzheimer’s disease pathophysiology

HIGHLIGHTS

• who: Reduced RAN Expression and colleagues from the University Medical Centre, Maastricht, The Netherlands, Collaborative Sequencing Center, Translational Genomics Research Institute, Phoenix, Arizona, United States of have published the paper: Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer’s Disease Pathophysiology, in the Journal: PLOS ONE | www.plosone.org of September/18,/2012
• what: The authors propose a model in which transcription regulators in the nucleus and their increased presence in the cytoplasm may lead to many of the cellular manifestations of Alzheimer's disease. The authors show . . .
  

   

  

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