HIGHLIGHTS
SUMMARY
Episodic memory decline and medial temporal lobe (MTL) atrophy are markedly the most prominent and earliest pathological changes associated with age-related cognitive decline including Alzheimers Disease (Gomez-Isla et_al, 1996; Price et_al, 2001; Braak and Braak, 1991; Jack et_al, 1999). A key circuit of interest within the medial temporal lobe originates from the entorhinal cortex, 1 of the earliest sites of ac- cumulation of AD-related tau pathology (Desikan et_al, 2010; Desikan et 2012; Eskildsen et_al, 2013). The integrity of the perforant path is critical for normal hippocampal functioning, is vulnerable to the . . .
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