Reduction in pa28αβ activation in hd mouse brain correlates to increased mhtt aggregation in cell models

HIGHLIGHTS

• who: Karlijne W. Geijtenbeek and colleagues from the Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The have published the research: Reduction in PA28u03b1u03b2 activation in HD mouse brain correlates to increased mHTT aggregation in cell models, in the Journal: PLOS ONE of December/27,/2022
• what: The authors examined whether changes in proteasome complex formation occur during disease progression in HD mouse models.
• how: In this study HdhQ150 mice expressing endogenous full-length mouse Htt with an expanded CAG repeat and R6/2 mice expressing a human exon 1 HTT transgene . . .
  

   

  

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