Reenacting neuroectodermal exposure of hematopoietic progenitors enables scalable production of cryopreservable ipsc-derived human microglia

HIGHLIGHTS

  • who: Mona Mathews from the LIFE and BRAIN GmbH, Venusbergu2011Campus, Bonn, Germany have published the paper: Reenacting Neuroectodermal Exposure of Hematopoietic Progenitors Enables Scalable Production of Cryopreservable iPSC-Derived Human Microglia, in the Journal: (JOURNAL)
  • what: The authors report a developmentally informed in vitro differentiation method for large-scale production and cryopreservation of iPSC-derived (iPSdMiG). The majority of these in_vitro differentiation protocols aim at recapitulating developmental pathways relevant to cell type specification , and the pertinence of this approach has been impressively illustrated in the context of midbrain dopamine neuron generation. The study shows that . . .

     

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