Reformation of the chondroitin sulfate glycocalyx enables progression of ar-independent prostate cancer

HIGHLIGHTS

• who: Nader Al-Nakouzi from the Prostate tumors with loss of AR activity display elevated , and chondroitin sulfate levels We next validated the results from the PDX discovery model in prostate cancer patientsWe first determined the relationship between the identified , enzyme-coding genes (Fig., c) and androgen signaling in a clinical RNA-Seq dataset of , prostate cancer patient tumors at different disease stages (VPC cohort)39. We correlated expression of the , genes with an expression of five validated AR-regulated genes KLK3, NKX3.140, TMPRSS241-43, FKBP544, and , as readouts for AR signaling activity. Of the top . . .
  

   

  

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