HIGHLIGHTS
- who: Jie Qi from the CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute for Bioinformation, Beijing, China have published the research work: Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways, in the Journal: (JOURNAL)
- what: We showed that genes with 5hmC gain in GU tumors were associated with stemness, hypoxia or cross talk with the immune system, indicating that 5hmC alteration could serve as a hallmark signature for the tumorigenesis of GU cancers.
- how: The authors applied a sensitive immunoprecipitation-based method . . .
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