Regional infusion of a class c tlr9 agonist enhances liver tumor microenvironment reprogramming and mdsc reduction to improve responsiveness to systemic checkpoint inhibition

HIGHLIGHTS

  • who: Chandra C. Ghosh from the (UNIVERSITY) have published the article: Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition, in the Journal: (JOURNAL) of 14/06/2022
  • what: This study was designed to test the hypothesis that regional intravascular infusion of class C TLR9 agonists can reprogram the LM-MDSC compartment to create a more immuneresponsive TME. The authors demonstrate that regional infusion of a class C TLR9 agonist reduced MDSC abundance in LM and enhanced the antitumor efficacy of . . .

     

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