Regorafenib induces bim-mediated intrinsic apoptosis by blocking akt-mediated foxo3a nuclear export

HIGHLIGHTS

• who: Beini Sun from the (UNIVERSITY) have published the paper: Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export, in the Journal: (JOURNAL) of 10/Nov/2022
• what: The authors report for the first time that the PI3K/AKT/FOXO3a signaling pathway plays a key role in REGO-induced intrinsic apoptosis in breast cancer MCF-7 cells. The study showed that REGO induced Bax activation and translocation to mitochondria, which was prevented by KO Bim (Fig 4H), further demonstrating that Bim plays a key role in REGO-induced apoptosis by triggering . . .
  

   

  

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