Regression and classification of transcription factors’ specificity and methylation effects

HIGHLIGHTS

• who: Zheng Zuo from the Department of, Stanford University, Serra Mall, Stanford, CA, US have published the Article: Regression and Classification of Transcription Factors' Specificity and Methylation Effects, in the Journal: (JOURNAL)
• what: Note that this R.S.S.Methyl operates on a set of pairwise compared data between corresponding methylated and unmethylated sites, e_g, between CCGGATC and CMWGATC, which matches the experiment design of Methyl-Spec-seq well. The authors showed that all-in-one linear regression does not give the proper answer about the methyl effects of CTCF, primarily because the model ‘squeezes . . .
  

   

  

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