Regulation of atg4b stability by rnf5 limits basal levels of autophagy and influences susceptibility to bacterial infection

HIGHLIGHTS

• who: Ersheng Kuang and colleagues from the Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Department of Pediatrics, School of Medicine and Skaggs School of Pharmacy and have published the research work: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection, in the Journal: (JOURNAL) of October/18,/2012
• what: The authors show that the membrane-associated E3 ligase RNF5 regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B. Using RNF5 mutant mice the authors demonstrate . . .
  

   

  

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