Regulation of cell survival by sphingosine-1-phosphate receptor s1p1 via reciprocal erk-dependent suppression of bim and pi-3-kinase/protein kinase c-mediated upregulation of mcl-1

HIGHLIGHTS

• who: C Rutherford from the InstitutUniversity of Glasgow, Scotland, UK have published the research: Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1, in the Journal: (JOURNAL)
• what: The authors demonstrate that endogenous and recombinant S1P1 is able to suppress levels of proapoptotic BH3-only protein Bim via a mitogen-activated protein/ERK kinase (MEK)/ERK1,2 pathway, and enhance the accumulation of anti-apoptotic protein Mcl-1 via a PI3Kmediated and protein kinase . . .
  

   

  

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