Regulation of mitochondrial protein import by the nucleotide exchange factors grpel1 and grpel2 in human cells

HIGHLIGHTS

• who: Shubhi Srivastava from the (UNIVERSITY) have published the research: Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells, in the Journal: (JOURNAL) of March/27,/2017
• what: The authors report that two putative NEF orthologs, GrpE-like 1 (GrpEL1) and GrpEL2, modulate mtHsp70's function in human cells. The authors propose diversification of human NEF into two paralogs, EL1 and EL2, for better maintenance of mitochondrial functions. Similarly, for the analysis of EL1 and EL2 interaction, biotinylated GrpEL1 was immobilized as ligand, and increasing concentrations of GrpEL2 . . .
  

   

  

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