HIGHLIGHTS
SUMMARY
PDF signaling starts following its release by specific pacemaker neurons, whose period of activity in_vivo tracks the dawn in a variety of photoperiodic conditions. The PDF receptor (PDFR) is a member of the Family B (secretin receptor-like) GPCR group: it is Gs-coupled and its activation elevates cAMP levels in_vivo. The working hypothesis was that, by their actions in_vivo, such modified PDF receptors would reveal extended lifetimes of activation. Sensitivity to PDF in_vivo peaks in the early day and is regulated by the PER-dependent clock, via post-transcriptional mechanisms: the EC50 for . . .
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