HIGHLIGHTS
- who: Bastiaan, Dekker and Job, Dekker from the DepartmentUniversity of have published the paper: Regulation of the mitotic chromosome folding machines, in the Journal: (JOURNAL) of 21/Oct/2022
- what: The authors focus on condensins, topoisomerase IIa and KIF4A as the main machines that fold and organize mitotic chromosomes but acknowledge that cohesin is also contributing through mediating connections between sister chromatids. The authors focus on how regulatory mechanisms involving cell cycle-regulated gene_expression, phosphorylation/dephosphorylation, ubiquitination and other modifications, and associations with other complexes, regulate the machinery that folds mitotic chromosomes as cells enter . . .
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