Regulation of the sphingoid long-chain base kinase lcb4p by ergosterol and heme

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• who: Takamitsu Sano from the Takamitsu Sano, Akio Kihara1, Fumiko Kurotsu, Soichiro Iwaki, and Yasuyuki Igarashi From the Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita, jo, Nishi, choume, Kita-ku, Sapporo, Japan Sphingoid long-chain base, phosphates (LCBPs) are widely conserved, bioactive lipid moleculesIn yeast, LCBPs are known to be involved in several cellular responses such as heat shock resistance and Ca2ⴙ mobilization, although their target molecules and signaling pathways remain unclear. To identify genes involved in LCBP signaling and in regulation of LCBP synthesis, we performed transposon mutagenesis in . . .
  

   

  

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