Regulation of thiamine and pyruvate decarboxylase genes by pdc2 in nakaseomyces glabratus (candida glabrata) is complex

HIGHLIGHTS

• What: Unfortunately, no genome-wide chromatin im­ munoprecipitation (ChIP) studies have been performed with ScPDC2, likely because Scpdc2Δ is lethal in high glucose conditions, and as the authors show here, the interaction of ScPdc2 is weak with DNA using a ChIP assay. The authors show that NgPdc2 binds more strongly in_vivo to THI promoters during thiamine starvation than ScPdc2, the DBD of NgPdc2 binds DNA relatively nonspecifically, and that NgThi3 colocalizes with NgPdc2 at most promoters. The authors demonstrate that regulation of THI promoters is surprisingly complex and THI promoters have different characteristics than a recently acquired . . .
  

   

  

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