Regulation of transcriptional activity of merkel cell polyomavirus large t-antigen by pka-mediated phosphorylation

HIGHLIGHTS

• who: Mar Falquet and colleagues from the Molecular Inflammation Research Group, Department of Medical Biology, University of TromsMicrobiology of Chronic Neuro-Degenerative Pathologies, IRCSS San Raffaele, Rome, Italy have published the paper: Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation, in the Journal: (JOURNAL) of 13/Dec/2022
• what: Substitution of serine residues 191, 203 and 265 into non-phosphorylable Ala or phosphomimicking Asp did not alter the transcriptional repression activity of MCPyV LTag on the viral promoters.
• how: As MCPyV LTag has been shown to . . .
  

   

  

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