HIGHLIGHTS
- who: Thomas Andreska from the Institute of Clinical Neurobiology, University Hospital Wuerzburg, Wuerzburg, Germany have published the paper: Regulation of TrkB cell surface expression—a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor, in the Journal: (JOURNAL)
- what: This work showed that dopamine addition potentiated the effects of BDNF on the differentiation of tyrosine hydroxylase- positive striatal neurons.
- how: A similar observation was made in hippocampal neurons in which TrkB phosphorylation of Ser478 in the juxtamembrane cytoplasmatic region by cLTP-induced cyclin-dependent kinase 5 (Cdk5) activity leads to rapid . . .
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