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- who: Cross-species genetic screens identify et al. from the College University of Minnesota, Minneapolis, Minnesota, USA have published the Article: regulator of polyglutamineexpanded ataxin-1 Integrative Molecular and Biomedical Science Program and 2Department, in the Journal: (JOURNAL)
- what: The work provides a molecular insight into SCA1 pathogenesis and an opportunity for allele-specific targeting for neurodegenerative disorders. Autophagy dysfunction is also unlikely to hinder the clearance of ATXN1 in premanifest SCA1 for the following reasons: 1) ATXN1 levels consistently decreased upon TG5 inhibition across different cell lines and patient iPSC-derived neurons; 2) mutant . . .
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