HIGHLIGHTS
- who: Dan Wang from the (UNIVERSITY) have published the research: Regulatory pathways and drugs associated with ferroptosis in tumors, in the Journal: (JOURNAL)
- future: The information summarized in the paper is not enough to support the application of ferroptosis inducers in cancer more ncRNAs identification and further studies are needed.
SUMMARY
It can catalyze the oxidation of GSH to GSSG and peroxidize reduced polyunsaturated_fatty_acids, thereby protecting the phospholipid bilayer in the cell from oxidative damage and inhibiting ferroptosis. Specifically, ACSL4 has a preference for longchain polyunsaturated_fatty_acids, such as arachidonic acid (AA . . .
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