Regulome analysis in b-acute lymphoblastic leukemia exposes core binding factor addiction as a therapeutic vulnerability

HIGHLIGHTS

• who: Jason P. Wray from the (UNIVERSITY) have published the Article: Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability, in the Journal: (JOURNAL) of 17/04/2021
• what: The authors characterize the ETV6-RUNX1 regulome by integrating chromatin immunoprecipitation- and RNA-sequencing and show that ETV6-RUNX1 functions primarily through competition for RUNX1 binding_sites and transcriptional repression. Strikingly, the authors show that RUNX1 addiction extends to other genetic subtypes of pediatric B-ALL and also adult disease. The authors show that ETV6-RUNX1 interacts with chromatin through . . .
  

   

  

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