HIGHLIGHTS
- who: Xu Zhang from the (UNIVERSITY) have published the Article: Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance, in the Journal: (JOURNAL) of 17/08/2021
- what: The authors show that senescence and inflammatory expression profiles increase with age and are brain region- and sex-specific. p16-positive myeloid cells exhibiting senescent and disease-associated activation signatures, including upregulation of chemoattractant factors, accumulate in the aged mouse brain. The authors focused on the hippocampal dentate gyrus, an adult neurogenic niche susceptible to deleterious inflammatory remodeling in the . . .
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