HIGHLIGHTS
- who: Jack Henningfield from the University of have published the article: REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats, in the Journal: Scientific Reports Scientific Reports of 22/Nov/2021
- what: This work has been audited by Quality Assurance of Charles River Laboratories, Inc. This study was designed and conducted in accordance with the 2017 FDA Guidance on the Assessment of Abuse Potential of u00adDrugs24 to assess the potential of REL-1017 to engender physical dependence and/or withdrawal symptoms/signs (Fig 2, Drug . . .
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