HIGHLIGHTS
SUMMARY
To evaluate associations between ERK or Akt signaling dynamics and cell division, the authors first conducted a series of live cell imaging experiments in MCF10A cells that express either E RK41,65 or A kt43 kinase translocation reporters (KTRs), but not yet both at once, and paired those single cell dynamics to cell division events (Fig 1A). The authors first verified that cell cycle progression and division are related to ERK and Akt activity dynamics in MCF10A cells using small_molecule inhibitor experiments (Fig S1). After acquiring 1 h of baseline ERK or Akt activity . . .
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