Relevance of amorphous and amyloid-like aggregates of the p53 core domain to loss of its dna-binding activity

HIGHLIGHTS

• who: Hibino E and collaborators from the Laboratory of Structural Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan, BeCellBar LLC, Nagoya University, Nagoya, Japan have published the research: Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity, in the Journal: (JOURNAL)
• what: The authors focused on several additives (salts and osmolytes), which are important for cell maintenance. Considering these results together, the authors propose that the DNAbinding ability of both p53-wt and p53-R175H can be retained by the addition of . . .
  

   

  

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