HIGHLIGHTS
SUMMARY
Recent studies have revealed that some repair proteins accumulate at DNA damaged sites by forming a liquid-liquid phase separation (LLPS). The authors will then discuss evidence of LLPS in the context of DNA repair and the limitation of this model to fully describe structures formed at damaged sites. Some HR proteins inside foci rapidly exchange with the nuclear proteins, such as Rad52 in yeast, RAD52 and RAD54 in mammalian cells, while other HR proteins appear stably associated with repair foci (RAD51 in mammalian cells or Rfa1 in yeast ). In a simple model named . . .
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