Repeated exposure of macrophages to synthetic amorphous silica induces adaptive proteome changes and a moderate cell activation

HIGHLIGHTS

SUMMARY

Paradigm, studies of the toxicological impact of SAS have focused on the persistence of the effects on in_vivo model and on macrophage models for in_vitro systems (as reviewed for example). In vivo studies have shown that the effects of SAS are transient, which has been recently transposed (and confirmed) using dedicated in_vitro systems. Such exposures are, by definition, repeated exposures, and it was thus necessary to use a repeated exposure scheme to reproduce the in_vivo reality as closely as possible in the in_vitro experiments. The stronger difference was, however, observed for IL-6, which . . .

 



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