Replication fork arrest and rdna silencing are two independent and separable functions of the replication terminator protein fob1 of saccharomyces cerevisiae*

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• who: Narendra K. Bairwa from the Narendra KBairwa1, Shamsu Zzaman1, Bidyut K. Mohanty1, and Deepak Bastia, From the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina , The replication terminator protein Fob, of Saccharomyces cerevisiae is multifunctional, and it not only promotes polar replication fork arrest at the tandem Ter sites located in the intergenic spacer region of rDNA but also loads the NAD-dependent histone deacetylase Sir, at Ter sites via a protein complex called RENT (regulator of nucleolar silencing and telophase exit). Sir, is a component of the RENT complex . . .
  

   

  

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