Repositioning linifanib as a potent anti-necroptosis agent for sepsis

HIGHLIGHTS

• who: Liang Yu from the mice (8, weeks old) were purchased from Beijing Vital River Laboratory Animal Technology Co [, ]Ltd. (Beijing, China). Mice were raised in an SPF facility with a pathogenu2010free environment (, u00b1 , u00b0C and , u00b1, % humidity) with a, :, h light/dark cycle at the Three Gorges University Laboratory Animal Center. Mice were administered Nec-1/linifanib or solvent CMC-Na by p.o. gavage at the indicated doses , min before i.v. injection of TNF-u03b1 (, u03bcg). TNF-u03b1 was diluted in PBS and injected i.v. (, u00b5g/mouse) in a volume of , u03bcl. Body . . .
  

   

  

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