Repositioning mifepristone as a leukaemia inhibitoryfactor receptor antagonist for the treatment ofpancreatic adenocarcinoma

HIGHLIGHTS

  • who: Cristina Di Giorgio and colleagues from the Department of Medicine and Surgery, University of Perugia, Perugia, Italy have published the paper: Repositioning Mifepristone as a Leukaemia InhibitoryFactor Receptor Antagonist for the Treatment ofPancreatic Adenocarcinoma, in the Journal: Cells 2022, 11, 3482. of /2022/
  • what: The main reason for the dismal prognosis of PDAC is a late diagnosis, since u224890% of cancer is detected after spreading beyond the pancreas, with 2 of 23 systemic metastases occurring in >50% of patients at the time of diagnosis and only 20% of patients meeting the criteria for surgery . . .

     

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