HIGHLIGHTS
- who: Lendel Correia da Costa from the (UNIVERSITY) have published the paper: Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models, in the Journal: (JOURNAL)
- what: This study aims to provide a possible use of CRISPR/dCas9 DNA recognition system fused with KRAB domain to maintain a repressive state in a latentinfected lymphoid and myeloid cell models, upon PKC agonists or HDAC inhibitor (HDACi) stimulation. In agreement with previous studies which prove that KRAB domain is essential for HIV-1 latency, the study demonstrated that the KRAB fused . . .
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