Reprogramming dysfunctional cd8+ t_cells to promote properties associated with natural hiv control

HIGHLIGHTS

• who: Federico Perdomo-Celis and colleagues from the Institut(DMU), INSERM, CESP, Le Kremlin Bicu00eatre, France have published the article: Reprogramming dysfunctional CD8+ T_cells to promote properties associated with natural HIV control, in the Journal: (JOURNAL)
• what: The authors show that targeting the signaling pathways Wnt/transcription factor T cell factor 1 (Wnt/TCF-1) and mTORC through GSK3 inhibition to reprogram HIV-specific CD8+ T cells from noncontrollers promoted functional capacities associated with natural control of infection. The authors evaluated the potential of CD8+ T_cell reprogramming to induce stem-like properties in cells derived . . .
  

   

  

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