Repurposing the lineage-determining transcription factor atoh1 without redistributing its genomic binding sites

HIGHLIGHTS

• who: TYPE and colleagues from the University of Leicester, United Kingdom have published the research: Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites, in the Journal: (JOURNAL)
• what: The authors demonstrate that Atoh1 can activate a neuronal programme in mESCs and confirm that Gfi1 and Pou4f3 convert Atoh1 to a sensory HC determinant. The authors focused the subsequent analysis on genes within cluster 1 and 2. The authors propose that Gfi1 additionally acts as a co-activator of Atoh1 target genes.
• how: Data were analysed with FlowJo software . . .
  

   

  

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