Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes

HIGHLIGHTS

• What: The authors further explored the potential of hiPSC-derived OSCs to rescue immature denuded human oocytes retrieved in conventional COS cycles, and the authors determined how gene_expression is modulated in oocytes and OSCs by OSC-IVM co-culture. Collection of immature oocytes Subject ages, IRB, and informed consent Forty-seven fertility patient subjects were enrolled in the study for donating oocytes for research purposes using informed consent (IRB# 1345762, Western IRB and CNRHA 47/428973.9/22). Oocyte retrieval and donation Fertility patients providing discarded immature oocytes had signed informed consents, provided by the clinic, permitting . . .
  

   

  

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