Rescue of mitochondrial function in hutchinson-gilford progeria syndrome by the pharmacological modulation of exportin crm1

HIGHLIGHTS

• who: Feliciano Monterrubio-Ledezma et al. from the Department Genetics and Molecular Biology, Centro de Investigaciu00f3n y de Estudios Avanzados del Instituto Politu00e9cnico Nacional (CINVESTAV), Mexico City, Mexico Department Neuropathology, Instituto de Fisiologu00eda Celular, Universidad Nacional Autu00f3noma de have published the paper: Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1, in the Journal: Cells 2023, 275 of 14/Dec/2022
• what: The authors provide evidence that the beneficial effect LMB is mechanistically based on a combinatory effect on mitochondrial biogenesis via upregulation PGC-1u03b1 expression (master transcription . . .
  

   

  

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