HIGHLIGHTS
- who: Aging et al. from the of its safe profile and multifactorial functionsWe can only speculate on the potential molecular mechanisms underlying the observed phenotype, especially considering that although metformin and other biguanides are known to work by inhibiting hepatic gluconeogenesis, its precise mechanisms of action remain widely debated. Nir Barzilai and collaborators have shown that , weeks of metformin can improve age-associated metabolic derangements in glucose intolerant older adults: the treatment had tissueu2010specific effects on gene expression and influenced not only metabolic genes and pathways, but also collagen and mitochondrial genes in adipose tissue, and DNA . . .
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