HIGHLIGHTS
- who: Hypoxia and collaborators from the (UNIVERSITY) have published the research work: RESEARCH Open Access, in the Journal: (JOURNAL)
- what: The authors identified a novel hypoxia-responsive circRNA generated from INSIG1 gene, termed as circINSIG1, which was shown to be modulated by hypoxiainduced EIF4A3.
- how: The results showed that a spanning junction ORF with the potential to encode a 121 amino_acid protein (referred as circINSIG1-121 hereafter) and an IRES at 207-292 nt were contained in the sequence of circINSIG1 (Fig 2A). The results indicated that circINSIG1 could be detected in the . . .
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