HIGHLIGHTS
- who: Min Deng from the Affiliated Hospital and Institute of Guangzhou Medical University, Tumor Treatmentu201d, Guangzhou, China have published the article: RESEARCH Open Access, in the Journal: (JOURNAL)
- what: The authors investigated the status of mRNA modifications in GC and discovered that ac4C mRNA modification and its acetyltransferase NAT10 are significantly upregulated in GC. The studies demonstrated the novel ac4Cdependent function of NAT10 in promoting malignant progression of GC through mediating ac4C acetylation of MDM2 mRNA and uncovered a previously unrecognized signaling cascade involving the Hp-NAT10-MDM2-p53 axis during GC development.
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