Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma

HIGHLIGHTS

  • who: Yiwei Xu and collaborators from the Bose Institute, India University of Alabama at Birmingham have published the Article: Research progress of abnormal lactate metabolism and lactate modification in immunotherapy of hepatocellular carcinoma, in the Journal: (JOURNAL)
  • what: Multiple evidence shows that lactate plays an important role in regulating tumor cell metabolic reprogramming, remodeling TME, and regulating anti-tumor immunity, and lactate modification is an important way for lactate to function.
  • how: ChIPseq data showed that H3K18la like H3K18ac was enriched in the promoter region (u00b1 2 kb around the transcription start site . . .

     

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