Residues of trpm8 at the lipid-water-interface have coevolved with cholesterol interaction and are relevant for diverse health disorders

HIGHLIGHTS

• What: The authors demonstrate that the amino acids present in the LWI region are more conserved than the transmembrane or even full-length TRPM8 suggesting strong selection pressure in these residues. The authors explore the molecular evolution of amino_acids located in the lipid-water-interface region of the TRPM8 as well as in different cholesterol-binding motif sequences. The authors demonstrate that LWI-regions of TRPM8 could be the critical regions in the whole protein structure that might have contributed for TRPM8 selection throughout the vertebrate evolution. The individual accession numbers used for the analysis are also . . .
  

   

  

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