Resistance to energy metabolism – targeted therapy of aml cells residual in the bone marrow microenvironment

HIGHLIGHTS

• who: Yoko Tabe and Marina Konopleva from the Department of Laboratory Medicine, Juntendo University, Tokyo, Japan have published the Article: Resistance to energy metabolism - targeted therapy of AML cells residual in the bone marrow microenvironment, in the Journal: (JOURNAL)
• what: The authors evaluate potential therapeutic regimens combining OXPHOS and FAO inhibitors to target the metabolic vulnerabilities of BM-resident chemoresistant leukemia cells and LSCs.
• future: A more comprehensive understanding of the mechanisms of AML cell metabolism in future studies may reveal new treatment options targeting OXPHOS and FAO enhance the efficacy of chemotherapeutic . . .
  

   

  

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