HIGHLIGHTS
- who: Elisa Bisicchia from the (UNIVERSITY) have published the research work: Restoration of ER proteostasis attenuates remote apoptotic cell death after spinal cord injury by reducing autophagosome overload, in the Journal: (JOURNAL) of 10/Oct/2021
- what: In this study, using a model of spinal cord hemisection, the authors demonstrate that in remote axotomized neurons of the RN- functionally and anatomically connected to the injured spinal cord -SCI concurrently induces ER stress and reduces lysosomal biogenesis, leading to the blockade of autophagic flux and, consequently, neuronal apoptotic cell death. The aim of this study was . . .
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