Restoration of lipid homeostasis between tg and pe by the lxrα-atgl/ept1 axis ameliorates hepatosteatosis

HIGHLIGHTS

• who: Yulian Chen from the Animals Wild-type C BL/, mice were purchased from the laboratory animal center of Southern Medical University (Guangzhou, Guangdong, China)LXRu03b1-/- mice (KOCMP-21253-Nr1h3) have been established by the CRISPR/ Cas, system and validated Cyagen Biosciences (Guangzhou) Inc. (Guangzhou, Guangdong, China). The mice were identified by PCR genotyping and expression profiling (Supplementary Fig., ). Genotyping of mice was performed with primers, :, `-CTGCAACCAACACCAGTCTTCAATC-3`, :, `-CTAAAGCAAGAATGAAGGCCACTGC-3` and, :, `CTCTGCAATCGAGGTGGCTGGAAAG-3`, resulting in a , bp fragment for homozygotes and a, bp fragment for the wild-type allele. LXRu03b1 knockout (LXRu03b1-/-) mice were identified by PCR . . .
  

   

  

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